Protein engineering

نویسندگان

چکیده

Protein engineering is the creation of new amino acid sequences to modify proteins. There are many potential applications where addition, deletion or modification acids can aid hinder enzyme efficacy. As our knowledge genetics has expanded rapidly, so how this might be applied in reality. Proteins coded for by 20 found nature – should we limit efforts those acids? This issue also looks at research which trying see if move beyond 20-code language proteins, could offer us and protein functions?Why do need this? The world under pressure feed more people sustainable ways treat with medicine created efficiently sustainably. methods help reach goal, producing food possibly from unlikely sources, such as pathogenic bacteria like Yersinia pestis, causative agent plague create lab-grown meat. Sustainable farming supported engineering, reducing carbon footprint crops supporting greater yields. I it interesting that human race removed genetic diversity over time through techniques, now explore introducing order make work harder resilient pests climate change.There questions challenges area articles just some these. They give you an insight into reality.As always, covers personal experiences biochemistry anyone interested careers check out interviews, includes interviews two past 10 years' Colworth Medal winners, Professor Helen Walden Dr Madan Babu, celebration award's 60th anniversary, write-ups visits. always love hearing about what field daily, roles have varied.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protein engineering.

The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential...

متن کامل

Engineering therapeutic protein disaggregases

Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Protein disaggregases that reverse protein misfolding and restore proteins to native structure, function, and localization could mitigate neurodeg...

متن کامل

Protein engineering: security implications

The rapid pace of research in the life sciences is generating a vast amount of new knowledge that has beneficial applications in industry, agriculture and medicine but could, in some cases, be misused for warfare and terrorism. This dilemma has not escaped the attention of security experts and politicians, who worry that infectious microorganisms could be genetically modified so as to increase ...

متن کامل

Engineering Cell-permeable Protein

The protein transduction technique enables the direct delivery of biologically active material into mammalian cells [for review see (1,2)]. For this one can make use of the translocating ability of so-called cell penetrating peptides (CPPs), also designated as protein transduction domains (PTDs). The TAT-CPP derived from the human immunodeficiency virus type 1 (HIV-1) Tat (trans-activator of tr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The biochemist

سال: 2023

ISSN: ['1740-1194', '0954-982X']

DOI: https://doi.org/10.1042/bio_2023_105